Molecular localization of cold compounds

  • No requirement for specialized radioactive compound management, storage, equipment, permits, or specializedemployees
  • Imaging the molecules after scaled syntheses thus incorporates costs for brain localization studies already in functioning costs of scale-up and stability studies
  • No alternative synthesis routes required to incorporate radio-labels or heavy metals in the clinical candidates
  • Extended shelf life of the cold compounds
  • Safe: the lack of non-ionizing agents signifies that even volatile compounds, such as anesthetics, can be studied safely
  • Non-invasive imaging modality without surgical procedures
  • Animals can be reused or retested on short time cycles
  • Fast and specific to the compound atomic composition
  • Time courses of compound brain localization obtainable

Added value

  • Proof in concept for brain exposure of new molecular types
  • Pre-filtering for clinical candidate selection
  • Applicable to rational drug design

Risk evaluation for imaging with ionizing agents

  • More information = better decision
  • Never randomly select compounds for radio-labeled biobiodistribution studies again!